反应详情

A mixture of 4-(2-chloroethyl)benzenesulphonamide (2.00 g), 1-acetylpiperazine (1.17 g), sodium iodide (1.37 g) and sodium bicarbonate (0.84 g) in n-butanol was heated under reflux with stirring for 66 hours. The mixture was cooled slightly and filtered. The filtrate was allowed to stand and the solid that crystallised out was filtered off and recrystallised from ethyl acetate/methanol to give the title compound (1.10 g), m.p. 203°-204.5° C.

1. temperaturewas heated
2. temperatureunder reflux
3. temperatureThe mixture was cooled slightly
4. filtrationfiltered
5. customthe solid that crystallised out
6. filtrationwas filtered off
7. customrecrystallised from ethyl acetate/methanol