反应详情

3-Butyryl-8-methoxy-4(1H)-quinolone (9.0 g, 0.037 mol) and phosphorus oxychloride (100 ml) were heated under reflux for 30 minutes. When cool, the mixture was poured onto ice, adjusted to pH 4 with sodium bicarbonate and extracted with dichloromethane. Evaporation and crystallisation from ethyl acetate-petroleum ether gave 3-butyryl-4-chloro-8-methoxyquinoline (5.5 g, 58.5%), m.p. 114°-116°.

1. temperatureunder reflux for 30 minutes
2. temperatureWhen cool
3. additionthe mixture was poured onto ice
4. extractionextracted with dichloromethane
5. customEvaporation and crystallisation from ethyl acetate-petroleum ether