1-Phenylpiperazine → 1-(2-Methoxyphenoxy)-4-(4-phenyl-1-piperazinyl)-2-butanol

HRID 1382398Notes

Reaction equation

HRID 1382398 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH:16]([OH:27])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH3:26].C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[CH3:26][O:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[O:18][CH2:17][CH:16]([OH:27])[CH2:15][CH2:14][N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 131203504-Chloro-1-(2-methoxyphenoxy)-2-butanol

Product 1

HCID 144228731-(2-Methoxyphenoxy)-4-(4-phenyl-1-piperazinyl)-2-butanolYield 64%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 78. A mixture of 3.2 g (0.02 mole) of 1-phenylpiperazine, 4.8 g (0.02 mole) of 4-chloro-1-(2-methoxyphenoxy)-2-butanol and 8.0 g (0.075 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 4.5 g (64%) of white powder, m.p. 101°-102° C. Recrystallizing solvent used was iropropyl alcohol.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a29779eaf3474e9b8cc6978136ef45cd
Source dataset
uspto-grants-1989_02
Patent number
US04806555

Reaction notes

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