1-Phenylpiperazine → HCID 14422859, compound

HRID 1382399Notes

Reaction equation

HRID 1382399 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:14][CH2:15][CH:16]([OH:29])[CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[F:26][C:25]([F:27])([F:28])[C:21]1[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=1)[O:18][CH2:17][CH:16]([OH:29])[CH2:15][CH2:14][N:10]1[CH2:11][CH2:12][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 10340Sodium CarbonateHCID 131203482-Butanol, 4-chloro-1-[3-(trifluoromethyl)phenoxy]-

Product 1

HCID 14422859HCID 14422859, compoundYield 42.3%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

This compound was prepared according to the procedure of Example 78. A mixture of 2.4 g (0.015 mole) of 1-phenylpiperazine, 4.0 g (0.015 mole) of 4-chloro-1-(3-trifluoromethylphenoxy)-2-butanol and 5.3 g (0.05 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 2.5 g (42%) of a tan powder, m.p. 73°-74° C. Recrystallizing solvent used was ligroin.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-b824cadb4d9d4d5eb95aeb306fe5b09f
Source dataset
uspto-grants-1989_02
Patent number
US04806555

Reaction notes

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