HRID1382416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID83113

4-(4-Tolyl)piperazine

C11H16N2

HCID13120349

未命名化合物

PRODUCTS

生成物

HCID313

Hydrochloric Acid

ClH

结构：Cc1ccc(N2CCN(CCC(O)COc3ccc(Cl)cc3)CC2)cc1.Cc1ccc(N2CCN(CCC(O)COc3ccc(Cl)cc3)CC2)cc1.Cl.Cl.O.O.O

HCID131715862

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID263

1-Butanol

C4H10O

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

This compound was prepared according to the procedure of Example 97. A mixture of 1.8 g (0.01 mole) of 1-(4-methylphenyl)piperazine, 2.4 g (0.01 mole) of 4-chloro-1-(4-chlorophenoxy)-2-butanol, 5.2 g (0.05 mole) of anhydrous sodium carbonate and 0.1 g of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloride was formed in 2-propanol saturated with hydrogen chloride and the collected solid was recrystallized from ethanol-water-ethyl ether to give 1.4 g (31%) of white solid, m.p. 190°-195° C.

WORKUP

后处理

customThis compound was prepared
customgave a golden oil as residue

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6a7b290c67f749a1bda5046156130165
来源数据集: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04806555
来源说明: uspto-grants-1989_02

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Cl:14][CH2:15][CH2:16][CH:17]([OH:27])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=1.C(=O)([O-])[O-:29].[Na+].[Na+].[I-].[K+]>CC(O)C.C(O)CCC>[OH2:19].[ClH:14].[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH:17]([OH:27])[CH2:16][CH2:15][N:11]2[CH2:12][CH2:13][N:8]([C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)[CH2:9][CH2:10]2)=[CH:21][CH:22]=1.[OH2:29].[OH2:19].[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH:17]([OH:27])[CH2:16][CH2:15][N:11]2[CH2:12][CH2:13][N:8]([C:5]3[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=3)[CH2:9][CH2:10]2)=[CH:21][CH:22]=1.[ClH:14].[ClH:14]