Water → HCID 10380380, compound

To a solution of 9.6 g (39.6 mmol) of (4R,8R)-4,8,12-trimethyltridecanol in 30 mL of anhydrous N,N-dimethylformamide was added 10.7 g (40.84 mmol) of triphenylphosphine. The solution was stirred in an acetone-ice bath (-10° C.) while 2.1 mL (41 mmol) of bromine was added dropwise. The temperature rose to 5° C. The reaction mixture was stirred at room temperature for 1 hr then poured into 100 mL of water and 150 mL of hexane. After filtration, the layers were separated and the aqueous phase was extracted with 2×150 mL of hexane. The hexane layers were washed with saturated NaHCO3 solution, dried (MgSO4), filtered through a plug of silica gel, and concentrated in vacuo. Kugelrohr distillation (150°-160° C. bath temperature, 1 mm Hg) of the residue gave 2 fractions: 5.15 g of 95.8% GC purity and 3.55 g of 97.9% GC purity (72.2% yield). Redistribution of the larger fraction gave (4R,8R)-1-bromo-4,8,12-trimethyltridecane as a colorless liquid bp 120° C. (0.15 mm) having a GC purity of 97.9%; [a]25D-3.01° (c 2.09, hexane).

1. additionwas added dropwise
2. customrose to 5° C
3. filtrationAfter filtration
4. customthe layers were separated
5. extractionthe aqueous phase was extracted with 2×150 mL of hexane
6. washThe hexane layers were washed with saturated NaHCO3 solution
7. dry with materialdried (MgSO4)
8. filtrationfiltered through a plug of silica gel
9. concentrationconcentrated in vacuo
10. distillationKugelrohr distillation (150°-160° C. bath temperature, 1 mm Hg) of the residue
11. customgave 2 fractions

ORD record

ord-884ef3cda6bb41ca921652cb46072580

Source dataset

uspto-grants-1989_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04806661