Sulfuric Acid → HCID 70377377, compound

HRID 1382652Notes

Reaction equation

HRID 1382652 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[CH3:6][N:7]([CH3:35])[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14](/[C:17](/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:18](\[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)/[C:19]([F:22])([F:21])[F:20])=[CH:13][CH:12]=1>C(O)(C)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:35][N:7]([CH3:6])[CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14](/[C:17](/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:18](\[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)/[C:19]([F:21])([F:22])[F:20])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 21274922HCID 21274922, compound

Product 1

HCID 70377377HCID 70377377, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.03 ml (0.55 mmoles) of 98% sulfuric acid are added to a solution of 0.205 g (0.5 mmoles) of (E)-1-[4-(2-dimethylaminoethoxy)-phenyl]-1,2-diphenyl-3,3,3-trifluoro-propene in 1.5 ml of isopropanol. The separated crystals are filtered off, washed with ether, and the crude product is recrystallized from isopropanol. 0.22 g (84.6%) of the aimed compound are obtained; m.p.: 150°-153° C.

Workup

  1. filtrationThe separated crystals are filtered off
  2. washwashed with ether
  3. customthe crude product is recrystallized from isopropanol

Sources & evidence

ORD record
ord-11dd88c4622b4ab6ac4bdca2c7bedbc5
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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