p-Toluenesulfonic acid → HCID 86742757, compound

HRID 1382654Notes

Reaction equation

HRID 1382654 reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.[NH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19](/[C:22](/[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[C:23](\[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)/[C:24]([F:27])([F:26])[F:25])=[CH:18][CH:17]=1>C(O)(C)C>[S:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=1)([OH:10])(=[O:9])=[O:8].[NH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:17]=[CH:18][C:19](/[C:22](/[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[C:23](\[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)/[C:24]([F:25])([F:26])[F:27])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 1329277277599-89-4

Product 1

HCID 86742757HCID 86742757, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution of 0.20 g (1 mmole) of p-toluenesulfonic acid in 1 ml of isopropanol is added to a solution of 0.30 g (0.8 mmoles) of (E)-1-[4-(2-aminoethoxy)-phenyl]-1,2-diphenyl-3,3,3-trifluoro-propene, prepared as described in Example 8, in 0.5 ml of isopropanol. The separated crystals are filtered off and washed with ether. 0.37 g (84%) of the aimed compound are obtained; m.p.: 162°-163° C.

Workup

  1. customprepared
  2. filtrationThe separated crystals are filtered off
  3. washwashed with ether

Sources & evidence

ORD record
ord-afe05480d6ad454fa346317a29bce5f1
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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