Hydrochloric Acid → HCID 14350502, compound

HRID 1382713Notes

Reaction equation

HRID 1382713 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11]3[C:13]([O:19]C)=[CH:14][CH:15]=[C:16]([O:17]C)[C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].Cl>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][C:10]3[C:16]([OH:17])=[CH:15][CH:14]=[C:13]([OH:19])[C:11]=3[N:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 14350500HCID 14350500, compound

Product 1

HCID 14350502HCID 14350502, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A 1.0 g portion of 2-(4-chlorophenyl)-4,7-dimethoxy-1H-benzimidazole, 1.40 g of aluminum chloride and 50 ml of toluene was heated at reflux for 2 hours, then cooled and poured into cold 3N hydrochloric acid. The resulting solid was collected and recrystallized from ethanol, giving 680 mg of the desired product, mp>300° C.

Workup

  1. temperatureat reflux for 2 hours
  2. temperaturecooled
  3. customThe resulting solid was collected
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-be80c0c0f7db4c64b2da912c059ac3c6
Source dataset
uspto-grants-1989_02
Patent number
US04808586

Reaction notes

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