1-Bromo-3-chloropropane → 3-(3,5-Di-tertiary butyl-4-hydroxyphenyl)-1-(3-chloropropyl)-1H-pyrazolo[3,4-b]pyridine

HRID 1382887Notes

Reaction equation

HRID 1382887 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[NH:18][N:17]=2)[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[Cl:25][CH2:26][CH2:27][CH2:28]Br>>[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:28][CH2:27][CH2:26][Cl:25])[N:17]=2)[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 178440702HCID 178440702, compound

Product 1

HCID 1361510163-(3,5-Di-tertiary butyl-4-hydroxyphenyl)-1-(3-chloropropyl)-1H-pyrazolo[3,4-b]pyridine

Procedure

3-(3,5-Di-tertiary butyl-4-hydroxyphenyl)-1-(3-chloropropyl)-1H-pyrazolo[3,4-b]pyridine, melting at 107°-109° C. is prepared by reacting the compound of Example 1 with 3-chloropropyl bromide in a similar manner as Example 9, and recrystallizing from acetonitrile.

Workup

  1. customrecrystallizing from acetonitrile

Sources & evidence

ORD record
ord-8509bc911bdd403486033f3e69f8a3d3
Source dataset
uspto-grants-1989_02
Patent number
US04808620

Reaction notes

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