反应详情

温度

60 °C

To a solution of 7.8 g of 3-(3,5-di-tertiary butyl-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine in 40 ml of dimethylformamide are added 4.9 g of potassium carbonate and 7.2 g of 2-methoxyethyl p-toluenesulfonate, and the mixture is stirred at 60° C. for 7 hours. The resulting mixture is poured into ice-cold water and the precipitate is extracted with toluene. The extract is washed with water, dried and concentrated. The residue is recrystallized from hexane to give 7.2 g of 3-(3,5-di-tertiary butyl-4-hydroxyphenyl)-1-(2-methoxyethyl)-1H-pyrazolo[3,4-b]pyridine as white crystals, melting at 111°-113° C.

1. additionThe resulting mixture is poured into ice-cold water
2. extractionthe precipitate is extracted with toluene
3. washThe extract is washed with water
4. customdried
5. concentrationconcentrated
6. customThe residue is recrystallized from hexane