反应详情

A solution of 2.0 g (3.8 mmol) of 1-(4,4-dimethyl-6-chromanyl)ethyltriphenylphosphonium bromide and 630 mg (3.8 mmol) of methyl 4-formylbenzoate in 100 ml of 1,2-epoxybutane was heated under reflux for 72 hours. The reaction mixture was then concentrated in vacuo to an oil. The oil was purified by column chromatography on silicic acid, eluting with ether-hexane (1:9). This afforded mg (27% yield) of the title compound as a solid, mp 92°-95° C.

1. temperatureunder reflux for 72 hours
2. concentrationThe reaction mixture was then concentrated in vacuo to an oil
3. customThe oil was purified by column chromatography on silicic acid
4. washeluting with ether-hexane (1:9)