Hydrochloric Acid → HCID 86742774, compound

HRID 1382924Notes

Reaction equation

HRID 1382924 reaction equation
[ClH:1].[NH2:2][C@@H:3]([CH3:15])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9].Cl>C(Cl)Cl>[ClH:1].[NH2:2][C@@H:3]([CH3:15])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86742775HCID 86742775, compound

Product 1

HCID 86742774HCID 86742774, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

89 g (374 mmol) of tert.butyl (S)-6-aminoheptanoate hydrochloride are dissolved in 1.3 l of methylene chloride. The solution is saturated with hydrogen chloride and heated to reflux for 4 hours. After filtering off and drying the precipitate formed there are obtained 60.8 g (89.5%) of (S)-6-aminoheptanoic acid hydrochloride, m.p. 157°-160°.

Workup

  1. temperatureheated
  2. temperatureto reflux for 4 hours
  3. filtrationAfter filtering off
  4. customdrying the precipitate
  5. customformed there

Sources & evidence

ORD record
ord-abde772deaed45efb80e78c9d02fc97f
Source dataset
uspto-grants-1989_02
Patent number
US04808605

Reaction notes

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