Lithium Hydroxide → 4-[[[5-(4-Acetyl-3-hydroxy-2-propylphenoxy)pentyl]thio]methyl]-1,3-oxathiolane-2,2-dipropanoic acid
Reaction equation
[C:1]([C:4]1[CH:36]=[CH:35][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][S:14][CH2:15][CH:16]2[CH2:20][O:19][C:18]([CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])([CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[S:17]2)=[C:6]([CH2:37][CH2:38][CH3:39])[C:5]=1[OH:40])(=[O:3])[CH3:2].[OH-].[Li+]>>[C:1]([C:4]1[CH:36]=[CH:35][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][S:14][CH2:15][CH:16]2[CH2:20][O:19][C:18]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[S:17]2)=[C:6]([CH2:37][CH2:38][CH3:39])[C:5]=1[OH:40])(=[O:3])[CH3:2]Participants
3
Procedure
The title compound was prepared according to the procedure of Example 3 using the ester produced in Example 4 (1.0 g, 0.0016 mol) and aqueous lithium hydroxide solution (2 M, 3.0 ml). Following the workup procedure of Example 3, 0.99 g (96%) of the product was obtained as a colorless oil.
Sources & evidence
- ORD record
- ord-0ae5d8ea350e4066a1bccdbc9c21f9d8
- Source dataset
- uspto-grants-1989_02
- Patent number
- US04808729
Reaction notes
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