Potassium Carbonate → HCID 14405913, compound

HRID 1383152Notes

Reaction equation

[SH:1][CH2:2][CH:3]1[CH2:7][O:6][C:5]([CH3:15])([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[S:4]1.[CH2:16]([C:19]1[C:29]([OH:30])=[C:28]([C:31](=[O:33])[CH3:32])[CH:27]=[CH:26][C:20]=1[O:21][CH2:22][CH2:23][CH2:24]Br)[CH2:17][CH3:18].C(=O)([O-])[O-].[K+].[K+]>>[C:31]([C:28]1[CH:27]=[CH:26][C:20]([O:21][CH2:22][CH2:23][CH2:24][S:1][CH2:2][CH:3]2[CH2:7][O:6][C:5]([CH3:15])([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[S:4]2)=[C:19]([CH2:16][CH2:17][CH3:18])[C:29]=1[OH:30])(=[O:33])[CH3:32]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 27752211-[4-(3-bromopropoxy)-2-hydroxy-3-propylphenyl]ethanone

HCID 14405953HCID 14405953, compound

Product 1

HCID 14405913HCID 14405913, compound

Procedure

The title compound was prepared according to the procedure of Example 2 using the mercaptan produced in Example 36 (1.5 g, 0.006 mol), 3-(2-n-propyl-3-hydroxy-4-acetylphenoxy)-1-bromopropane (1.9 g, 0.006 mol) and anhydrous potassium carbonate (2.5 g). The crude product was chromatographed on silica gel using 20% ethyl acetate/hexane as eluent to give 2.7 g (93%) of the product as an oil.

Workup

customThe crude product was chromatographed on silica gel using 20% ethyl acetate/hexane as eluent

Sources & evidence

ORD record: ord-ec6ec98142e14b21b6396d36d65ad56d
Source dataset: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04808729

Reaction notes

Loading…