HCID 21188002, compound → HCID 21187986, compound

HRID 1383432Notes

Reaction equation

HRID 1383432 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]=[C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:18][CH:19]=1)C1C=CC=CC=1>O1CCCC1.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]=[C:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[O:18][CH:19]=1

Participants

4

Reactant 1

HCID 21188002HCID 21188002, compound

Product 1

HCID 21187986HCID 21187986, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

0.7 g of 4-(2-benzyloxyphenyl)-2-phenyl-1,3-oxazole according to step (d) are hydrogenated in 30 ml of tetrahydrofuran in the presence of 0.1 g of Pd/C catalyst at 20-60° C. (5 bar). After the catalyst has been separated off the solvent is distilled off in vacuo and the residue remaining is chromatographed on silica gel (dioxane:hexane 1:5). Yield: 0.5 g (99%);

Workup

  1. customAfter the catalyst has been separated off the solvent
  2. distillationis distilled off in vacuo
  3. customthe residue remaining is chromatographed on silica gel (dioxane:hexane 1:5)

Sources & evidence

ORD record
ord-c7ff0bf161564707a3af2300d739ae8c
Source dataset
uspto-grants-2001_07
Patent number
US06255327B1

Reaction notes

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