HCID 21188020, compound → Phenol, 2-(2-phenyl-5-oxazolyl)-

HRID 1383441Notes

Reaction equation

HRID 1383441 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:17][CH:16]=1)C1C=CC=CC=1>O1CCCC1.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[N:17][CH:16]=1

Participants

4

Reactant 1

HCID 21188020HCID 21188020, compound

Product 1

HCID 11128316Phenol, 2-(2-phenyl-5-oxazolyl)-

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

0.55 g of 5-(2-benzyloxyphenyl)-2-phenyl-1,3-oxazole according to step (c) are hydrogenated in 30 ml of tetrahydrofuran in the presence of 0.1 g of Pd/C catalyst (10W) at about 60° C. (5.7 bar). After the catalyst has been separated off the solvent is distilled off in vacuo and the residue remaining is chromatographed on silica gel (dioxane:hexane 3:5).

Workup

  1. customAfter the catalyst has been separated off the solvent
  2. distillationis distilled off in vacuo
  3. customthe residue remaining is chromatographed on silica gel (dioxane:hexane 3:5)

Sources & evidence

ORD record
ord-2413310354814fb29d6a8830e629cc77
Source dataset
uspto-grants-2001_07
Patent number
US06255327B1

Reaction notes

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