Hydrochloric Acid → HCID 15391352, compound

HRID 1383443Notes

Reaction equation

HRID 1383443 reaction equation
[CH:1]1([CH:6]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[CH:25]=[CH:24][N:23]=[C:22]3[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:16][CH:15]=2)[C:7]([O:9]C(C)(C)C)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>O1CCOCC1>[CH:1]1([CH:6]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[CH:25]=[CH:24][N:23]=[C:22]3[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:16][CH:15]=2)[C:7]([OH:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86757109HCID 86757109, compound

Product 1

HCID 15391352HCID 15391352, compoundYield 103%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.0 g (7 mmol) of the compound from Example I are dissolved in 14 ml of dioxane, treated with 2 ml of conc. HCl and the solution is refluxed for 5 h. It is concentrated, the residue is taken up in CH2Cl2 and the solution is washed with water. 2.6 g (96%) of the title compound are obtained as an oil.

Workup

  1. temperaturethe solution is refluxed for 5 h
  2. concentrationIt is concentrated
  3. washthe solution is washed with water

Sources & evidence

ORD record
ord-aa451da6d0274600996a1144b232d4b4
Source dataset
uspto-grants-2001_07
Patent number
US06255330B1

Reaction notes

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