反应详情

The mixture of 4-benzhydrylsulfanyl-piperidine (12 mg, 0.0423 mmol, 1.0 eq.), N-(2-bromoethyl)phthalimide (11 mg, 0.0423 mmol, 1.0 eq.), K2CO3 (9 mg, 0.0635 mmol, 1.5 eq.), and NaI (9 mg, 0.0600 mmol, 1.4 eq.) in 2-butanone (5 ml) was refluxed for 2-3 hours. The mixture was then cooled to room temperature. The solvent was removed and the resulted residue was dissolved in CHCl3 (25 ml). The solution was washed with water (3×5 ml), then dried over anhydrous Na2SO4. After removed all solvent, the crude product 2-[2-(4-benzhydrylsulfanyl-piperidin-1-yl)-ethyl]-isoindole-1,3-dione was yielded (15 mg).

1. temperaturewas refluxed for 2-3 hours
2. customThe solvent was removed
3. dissolutionthe resulted residue was dissolved in CHCl3 (25 ml)
4. washThe solution was washed with water (3×5 ml)
5. dry with materialdried over anhydrous Na2SO4
6. customAfter removed all solvent