Tert-Butyl nitrite → HCID 21188101, compound

HRID 1383591Notes

Reaction equation

HRID 1383591 reaction equation
N[C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1/[C:21](/[Br:25])=[C:22](\[Br:24])/[CH3:23].N(OC(C)(C)C)=O>O1CCCC1>[C:19]([C:4]1[C:3](/[C:21](/[Br:25])=[C:22](\[Br:24])/[CH3:23])=[CH:2][N:6]([C:7]2[C:8]([Cl:18])=[CH:9][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:11][C:12]=2[Cl:13])[N:5]=1)#[N:20]

Participants

4

Reactant 2

HCID 10906Tert-Butyl nitriteHCID 21188112HCID 21188112, compound

Product 1

HCID 21188101HCID 21188101, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a stirred solution of 5-amino4-(E-1,2-dibromopropenyl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.06 g) in tetrahydrofuran (1.5 ml) was added t-butyl nitrite (0.05 ml). The reaction mixture was heated at 60° C. for two hours. The reaction mixture was then evaporated and the residue was purified by column chromatography on silica gel (5 g) eluted with hexane: dichloromethane (100:0 to 20:70). Combination and evaporation of suitable fractions gave the title compound as a white solid, m.p. 134-135° C.

Workup

  1. customThe reaction mixture was then evaporated
  2. customthe residue was purified by column chromatography on silica gel (5 g)
  3. washeluted with hexane: dichloromethane (100:0 to 20:70)
  4. customCombination and evaporation of suitable fractions

Sources & evidence

ORD record
ord-1ed5c7b81b5c4422b9f6e47726715bee
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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