Pyridine → HCID 70240411, compound

HRID 1383618Notes

Reaction equation

HRID 1383618 reaction equation
[OH:1][C@H:2]1[CH:16]=[C:15]2[C@:5]([CH3:17])([CH2:6][C:7]3[C:8](=[CH:14]2)[O:9][C:10](=[O:13])[C:11]=3[CH3:12])[C@@H:4]([CH3:18])[C@H:3]1[O:19][C:20](=[O:23])[CH2:21][CH3:22].N1C=CC=CC=1.[CH:30]1([C:33](Cl)=[O:34])[CH2:32][CH2:31]1>>[CH:30]1([C:33]([O:1][C@H:2]2[CH:16]=[C:15]3[C@:5]([CH3:17])([CH2:6][C:7]4[C:8](=[CH:14]3)[O:9][C:10](=[O:13])[C:11]=4[CH3:12])[C@@H:4]([CH3:18])[C@H:3]2[O:19][C:20](=[O:23])[CH2:21][CH3:22])=[O:34])[CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 77637Cyclopropanecarbonyl chlorideHCID 70240479HCID 70240479, compound

Product 1

HCID 70240411HCID 70240411, compoundYield 96%

Conditions

Temperature
25 °C

Procedure

The title compound (70 mg, 96%) was prepared in the same manner as in Example A3, except that the compound (60 mg, 0.19 mmol) prepared in Example A2, anhydrous pyridine (151 μl, 1.87 mmol), and cyclopropanecarbonyl chloride (68 μl, 0.75 mmol) were stirred at 25° C. for 30 min and the purification was performed by column chromatography on silica gel (toluene:ethyl acetate=20:1).

Workup

  1. customthe purification

Sources & evidence

ORD record
ord-22d6276544b541d391d8d023ac1c67e4
Source dataset
uspto-grants-2001_07
Patent number
US06255339B1

Reaction notes

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