反应详情

The product of EXAMPLE 69 (85 mg) was combined with methanol (7 mL), THF (4 mL) water (2 mL) and triethylamine (2 mL) at room temperature. After 1.5 hours the reaction was concentrated and the residue dissolved in EtOAc. The solution was washed with saturated aqueous NaHCO3 and brine. The organic layer was dried (Na2SO4). The concentrated residue was purified by flash chromatography on silica gel eluted with 0-50% EtOAc in hexane affording the title compound. HPLC/MS: 513.9 (M+I), 515.9 (M+3); Rt=4.05 min.

1. concentrationAfter 1.5 hours the reaction was concentrated
2. dissolutionthe residue dissolved in EtOAc
3. washThe solution was washed with saturated aqueous NaHCO3 and brine
4. dry with materialThe organic layer was dried (Na2SO4)
5. customThe concentrated residue was purified by flash chromatography on silica gel
6. washeluted with 0-50% EtOAc in hexane affording the title compound