Hydrochloric Acid → HCID 21188383, compound

HRID 1383755Notes

Reaction equation

HRID 1383755 reaction equation
[C:1]([CH2:4][O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1)(=[O:3])[NH2:2].[ClH:21].O>C(OCC)(=O)C>[ClH:21].[ClH:21].[N:8]1([CH2:7][CH2:6][O:5][CH2:4][C:1]([NH2:2])=[O:3])[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 21188361HCID 21188361, compound

Product 1

HCID 21188383HCID 21188383, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1.4 g (0.005 mol) of tert-butyl 4-(2-carbamoylmethoxyethyl)piperazine-1-carboxylate prepared in Example I.4.1. and 14 ml of a 3M solution of hydrochloric acid in ethyl acetate are introduced into a 50 ml three-necked round-bottomed flask fitted with a water-cooled condesner and a mechanical stirrer. The mixture is stirred at room temperature for 2 hours. The precipitate is filtered off and is washed with ethyl acetate. 1.3 g (100%) of 2-(1-piperazinyl)ethoxyacetamide dihydrochloride are obtained. NRM: δ: 3.4 (2H, t, 4.7 Hz); 3.49-3.66 (8H, m); 3.81 (2H, t, 4.7 Hz); 3.87 (2H, s); 6.2 (5H exchangeable, bm); 7.2-7.7; 10.2. Mass spectrum: 188 (MH+).

Workup

  1. temperaturecooled condesner and a mechanical stirrer
  2. filtrationThe precipitate is filtered off
  3. washis washed with ethyl acetate

Sources & evidence

ORD record
ord-b054953816ac49c49829ed54ea49afda
Source dataset
uspto-grants-2001_07
Patent number
US06255487B1

Reaction notes

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