反应详情

A mixture of 4-iodophenol (15.0 g, 68.2 mmol) and 1,2-dibromoethane (50 ml, 580 mmol) and potassium carbonate (14.0 g, 0.1 mol) was stirred and refluxed for 22 h. After cooling to r.t., the mixture was filtered, washed with ethyl acetate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane/ethyl acetate 40: 1 to 20:1) to afford the title compound (18.7 g, 84%) as a white solid.

1. temperaturerefluxed for 22 h
2. filtrationthe mixture was filtered
3. washwashed with ethyl acetate
4. concentrationconcentrated in vacuo
5. customThe residue was chromatographed on silica gel (Hexane/ethyl acetate 40: 1 to 20:1)