反应详情

温度

80 °C

A solution of 4-[3-bromopropoxy]-2-[(4-chlorophenoxy)methyl]-1-[3-[1-(t-butoxycarbonyl)piperidin-4-yl]propyl]benzimidazole (77 mg, 0.124 mmol, 1 eq) in anhydrous N,N-dimethylformamide (2 ml) was treated with potassium carbonate (51.3 mg, 0.37 mmol, 2 eq) and 2-[2-(piperidin-1-yl)ethyl]piperidine (0.19 mmol, 1.5 eq). The resulting mixture was stirred at 80° C. for six hours. The reaction was quenched by the addition of water (10 ml). The aqueous fraction was extracted with ethyl acetate (3×10 ml). The organic fractions were combined, washed with water (3×10 ml), brine (1×10 ml), and then dried over sodium sulfate. The solvents were removed in vacuo to yield an oily crude product which was purified by flash chromatography to provide the title product.

1. customThe reaction was quenched by the addition of water (10 ml)
2. extractionThe aqueous fraction was extracted with ethyl acetate (3×10 ml)
3. washwashed with water (3×10 ml), brine (1×10 ml)
4. dry with materialdried over sodium sulfate
5. customThe solvents were removed in vacuo
6. customto yield an oily crude product which
7. customwas purified by flash chromatography