反应详情

A solution of the product of Example 5 (1.28 g, 3.2 mmol) and sodium hydroxide (1.3 g) in THF (50 ml) is refluxed for 6 h, acidified to pH 1 (concentrated HCl), extracted with ethyl acetate and washed with water. After drying, the organic phase is concentrated on a rotary evaporator under vacuum at 40° C. and the product is washed with heptane.

1. extractionextracted with ethyl acetate
2. washwashed with water
3. customAfter drying
4. concentrationthe organic phase is concentrated on a rotary evaporator under vacuum at 40° C.
5. washthe product is washed with heptane