Hydrochloric Acid → HCID 70183556, compound

HRID 1384166Notes

Reaction equation

HRID 1384166 reaction equation
I[C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][C:19]=2[CH3:20])[C:16]([CH3:22])([CH3:21])[CH2:15][CH2:14][C:13]3([CH3:24])[CH3:23])=[CH2:9])[CH:5]=[CH:6][CH:7]=1.[OH-:25].[Na+].Cl.[CH2:28]1[CH2:32][O:31]C[CH2:29]1>>[CH3:20][C:19]1[C:10]([C:8]([C:4]2[CH:3]=[C:2]([CH:29]=[CH:28][C:32]([OH:31])=[O:25])[CH:7]=[CH:6][CH:5]=2)=[CH2:9])=[CH:11][C:12]2[C:13]([CH3:23])([CH3:24])[CH2:14][CH2:15][C:16]([CH3:21])([CH3:22])[C:17]=2[CH:18]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21185971HCID 21185971, compound

Product 1

HCID 70183556HCID 70183556, compound

Procedure

A solution of the product of Example 7 (1.5 g, 3.7 nmol) and sodium hydroxide (1.5 g) in THF (50 ml) is refluxed for 8 h, acidified to pH 1 (concentrated HCl), extracted with ethyl acetate and washed with water. After drying, the organic phase is concentrated on a rotary evaporator under vacuum at 40° C. and the product is washed with heptane.

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. customAfter drying
  4. concentrationthe organic phase is concentrated on a rotary evaporator under vacuum at 40° C.
  5. washthe product is washed with heptane

Sources & evidence

ORD record
ord-bd3037b269ea4574987581cb6ab6e66d
Source dataset
uspto-grants-2001_07
Patent number
US06258775B1

Reaction notes

Loading…