Hydrochloric Acid → HCID 70183798, compound

HRID 1384174Notes

Reaction equation

HRID 1384174 reaction equation
[CH3:1][C:2]1[C:3]([CH:16]([C:18]2[CH:19]=C([CH:25]=[CH:26][CH:27]=2)C(OC)=O)[CH3:17])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.[OH-:28].[Na+].Cl.[CH2:31]1[CH2:35][O:34][CH2:33][CH2:32]1>>[CH3:1][C:2]1[C:3]([CH:16]([C:18]2[CH:19]=[C:35]([CH:31]=[CH:32][C:33]([OH:28])=[O:34])[CH:25]=[CH:26][CH:27]=2)[CH3:17])=[CH:4][C:5]2[C:6]([CH3:14])([CH3:15])[CH2:7][CH2:8][C:9]([CH3:12])([CH3:13])[C:10]=2[CH:11]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21185935HCID 21185935, compound

Product 1

HCID 70183798HCID 70183798, compound

Procedure

A solution of the product of Example 19 (2.5 g, 6.4 mmol) and sodium hydroxide (2.5 g) in THF (50 ml) is refluxed for 4 h, acidified to pH 1 (concentrated HCl), extracted with ethyl acetate and washed with water. After drying, the organic phase is concentrated on a rotary evaporator under vacuum at 40° C. and the product is washed with heptane.

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. customAfter drying
  4. concentrationthe organic phase is concentrated on a rotary evaporator under vacuum at 40° C.
  5. washthe product is washed with heptane

Sources & evidence

ORD record
ord-f112a6eba6424686a972c8398f68a668
Source dataset
uspto-grants-2001_07
Patent number
US06258775B1

Reaction notes

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