Guanidine Hydrochloride → HCID 178432193, compound

HRID 1384294Notes

Reaction equation

HRID 1384294 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:5]2=[C:4]([N+]([O-])=O)[C:3]=1[C:16]([OH:18])=O.[ClH:19].[NH2:20][C:21]([NH2:23])=[NH:22]>>[Cl:19][C:4]1[C:3]([C:16]([NH:22][C:21]([NH2:23])=[NH:20])=[O:18])=[C:2]([CH3:1])[N:7]=[C:6]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:5]=12

Participants

3

Reactant 2

HCID 5742Guanidine HydrochlorideHCID 21186760HCID 21186760, compound

Product 1

HCID 178432193HCID 178432193, compoundYield 16%

Procedure

When the method of Inventive Example 17 was repeated using 2-methyl-4-nitro-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carboxylic acid (750.1 mg, 3.00 mmol) and guanidine hydrochloride (2.77 g, 29.0 mmol), chlorination of the nitro group occurred at the same time and the title compound (134.5 mg, 16.0%) was obtained as white powder.

Sources & evidence

ORD record
ord-f1b4a58986ef47b1b3d111abf2b958f7
Source dataset
uspto-grants-2001_07
Patent number
US06258829B1

Reaction notes

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