Hydrochloric Acid → 4-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one

HRID 1384367Notes

Reaction equation

HRID 1384367 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:30]4[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=4)([C:20]4[CH:21]=[N:22][C:23]5[C:28]([CH:29]=4)=[CH:27][CH:26]=[CH:25][CH:24]=5)[OH:19])[CH:16]=3)[N:11]=[C:10]([O:36]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([OH:19])([C:30]4[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=4)[C:20]4[CH:21]=[N:22][C:23]5[C:28]([CH:29]=4)=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:16]=3)[NH:11][C:10](=[O:36])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21186408HCID 21186408, compound

Product 1

HCID 224654174-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the same procedure as described in Example 1F, the title compound of 38A (81 mg, 0.16 mmol) was treated with HCl in aqueous THF to yield the title compound of example 38B (56.4 mg, 71% yield).

Sources & evidence

ORD record
ord-4bf6c32b92b34ab78458d78b29ceb6a8
Source dataset
uspto-grants-2001_07
Patent number
US06258824B1

Reaction notes

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