N-(4-chlorobenzyl)-phenylacetamide → HCID 21187008, compound

HRID 1384461Notes

Reaction equation

HRID 1384461 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[CH:10]=O)[CH2:4][CH2:3]1.[Cl:16][C:17]1[CH:33]=[CH:32][C:20]([CH2:21][NH:22][C:23](=[O:31])[CH2:24][C:25]2[CH:30]=[CH:29]C=[CH:27][CH:26]=2)=[CH:19][CH:18]=1.[CH3:34][O-].[Na+]>CN(C)C=O>[ClH:16].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:21][NH:22][C:23](=[O:31])[C:24]([C:25]2[CH:26]=[CH:27][C:10]([C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[CH:29][CH:30]=2)=[CH2:34])=[CH:32][CH:33]=1

Participants

5

Reactant 3

HCID 306763N-(4-chlorobenzyl)-phenylacetamideHCID 27955662-(4-Methylpiperazin-1-yl)benzaldehydeHCID 10942334Sodium Methoxide

Product 1

HCID 21187008HCID 21187008, compoundYield 24.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-(4-methylpiperazin-1-yl)benzaldehyde (0.091 g, 0.45 mmol), N-(4-chlorobenzyl)-phenylacetamide (0.127 g, 0.49 mmol) and N,N-dimethylformamide (2 mL) was treated with anhydrous sodium methoxide (0.072 g, 1.34 mmol) under a nitrogen atmosphere as above to give the title product as an amorphous solid, (0.029 g).

Sources & evidence

ORD record
ord-9e28617780a942a2ac9f74f9446084b2
Source dataset
uspto-grants-2001_07
Patent number
US06258953B1

Reaction notes

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