Hydrogen Bromide → [2-(2-Thienyl)ethylamino](2-chlorophenyl)acetamide hydrobromide

HRID 1384476Notes

Reaction equation

HRID 1384476 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])[C:10]([NH2:12])=[O:11].[BrH:20]>CC(C)=O>[BrH:20].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH:8][CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])[C:10]([NH2:12])=[O:11]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 9882604[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetamide

Product 1

HCID 21187054[2-(2-Thienyl)ethylamino](2-chlorophenyl)acetamide hydrobromide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

14.7 g (0.05 mol) of [2-(2-thienyl)ethylamino](2-chlorophenyl)acetamide, prepared as described in Example 7, is dissolve din 150 ml of acetone. To the solution 4 ml of 60% aqueous hydrogen bromide solution is added and the precipitated white crystals are filtered off, washed with acetone and dried.

Workup

  1. dissolutionis dissolve
  2. filtrationthe precipitated white crystals are filtered off
  3. washwashed with acetone
  4. customdried

Sources & evidence

ORD record
ord-3aa938a98c254de18ce0bedfd69008d4
Source dataset
uspto-grants-2001_07
Patent number
US06258961B1

Reaction notes

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