Pyrrolidine → 1-[2-(5-Methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indol-1-yl)-1-oxoethyl]pyrrolidine

HRID 1384813Notes

Reaction equation

HRID 1384813 reaction equation
[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]2[C:11]([CH2:22][C:23](O)=[O:24])=[N:12][N:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:14](=[O:15])[C:3]1=2.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[C:4]2[C:11]([CH2:22][C:23]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[O:24])=[N:12][N:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:14](=[O:15])[C:3]1=2

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 21183746HCID 21183746, compound

Product 1

HCID 211837511-[2-(5-Methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indol-1-yl)-1-oxoethyl]pyrrolidine

Procedure

The preparation is carried out as in Example 3.2, from 1 g (3 mmol) of 5-methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetic acid and from excess pyrrolidine. The product is recrystallized from propan-2-ol. 0.5 g (1.3 mmol) of solid is obtained.

Workup

  1. customThe product is recrystallized from propan-2-ol

Sources & evidence

ORD record
ord-f9523e29bbe249199e85b34f3e757d9e
Source dataset
uspto-grants-2001_07
Patent number
US06262045B1

Reaction notes

Loading…