2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21183923, compound

HRID 1384938Notes

Reaction equation

HRID 1384938 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]([Cl:9])=[O:8])[CH:3]=1.[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[N:12]=1>O1CCOCC1>[ClH:9].[NH2:10][C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[C:13]([N:25]2[CH2:30][CH2:29][N:28]([C:7]([C:4]3[CH:3]=[C:2]([CH3:1])[O:6][N:5]=3)=[O:8])[CH2:27][CH2:26]2)[N:12]=1

Participants

4

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 27368945-Methylisoxazole-3-carbonyl chloride

Product 1

HCID 21183923HCID 21183923, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 5-methylisoxazole-3-carbonyl chloride (0.41 g., 2.83 mmole) in dioxane was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (0.82 g., 2.83 mmole) in dioxane. The mixture was treated as described in the previous example to give the title compound having a m.p. of 271°-273° C. with decomposition.

Workup

  1. additionThe mixture was treated

Sources & evidence

ORD record
ord-5ad027bbdee6488d851fbfc3f88ada10
Source dataset
uspto-grants-2001_07
Patent number
US06262059B1

Reaction notes

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