Hydrochloric Acid → HCID 70238476, compound

HRID 1384978Notes

Reaction equation

HRID 1384978 reaction equation
[Br:1][C:2]1[CH:15]=[C:14]([CH3:16])[C:5]([O:6][CH2:7][C@H:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)=[C:4]([CH3:17])[CH:3]=1.[ClH:18]>CCOCC>[ClH:18].[Br:1][C:2]1[CH:15]=[C:14]([CH3:16])[C:5]([O:6][CH2:7][C@H:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)=[C:4]([CH3:17])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15895218HCID 15895218, compound

Product 1

HCID 70238476HCID 70238476, compoundYield 94.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

The (S)-3-(4-bromo-2,6-dimethylphenoxymethyl)piperidine in ether was treated with 1M solution of hydrochloric acid in ether (102 mL). The resulting white precipitate was filtered, and dried in vacuo to yield (S)-3-(4-bromo-2,6-dimethylphenoxymethyl)-piperidine hydrochloride (29.5 g, 94.5%), m.p. >280° C.

Workup

  1. filtrationThe resulting white precipitate was filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-56febc675637467d8f47c36e530ccb08
Source dataset
uspto-grants-2001_07
Patent number
US06262078B1

Reaction notes

Loading…