Hydrochloric Acid → HCID 21184182, compound

HRID 1384988Notes

Reaction equation

HRID 1384988 reaction equation
[CH3:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:3]=1[O:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])[CH2:7]1.[ClH:22]>CCOCC>[ClH:22].[CH3:1][C:2]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:3]=1[O:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][N:14]([CH3:15])[CH3:16])[CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21184172HCID 21184172, compound

Product 1

HCID 21184182HCID 21184182, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The 3-(2,6-dimethylphenoxymethyl)-1-(2-dimethylaminoethyl)piperidine solution was treated with a 1M solution of hydrochloric acid in ether (17.2 mL). The resulting precipitate was isolated by filtration, then dried under vacuum to give 3-(2,6-dimethylphenoxymethyl)-1-(2-dimethylaminoethyl)-piperidine hydrochloride (4.0 g, 71%), m.p. 263.2-263.5° C.

Workup

  1. customThe resulting precipitate was isolated by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-77254c2d3a6c43e5a2e56ab1908ede77
Source dataset
uspto-grants-2001_07
Patent number
US06262078B1

Reaction notes

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