O-Methylhydroxylamine hydrochloride → HCID 15545849, compound

HRID 1385113Notes

Reaction equation

HRID 1385113 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([NH:17][CH2:18][C:19]([OH:21])=O)=[O:16])[CH:13]=3)[C:8]([CH2:22][CH3:23])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[O:25]([NH2:27])[CH3:26]>>[CH3:26][O:25][NH:27][C:19]([CH2:18][NH:17][C:15]([C:12]1[CH:13]=[C:14]2[C:9]([C:8]([CH2:22][CH3:23])=[N:7][N:6]2[CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:10][CH:11]=1)=[O:16])=[O:21]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 21183686HCID 21183686, compound

Product 1

HCID 15545849HCID 15545849, compoundYield 16.1%

Procedure

This compound was prepared according to the method of Example 37, using 222 mg (0.704 mmol, 1.0 equiv)[(1-cyclopentyl-3-ethyl-1H-indazole-6-carbonyl)-amino]-acetic acid and 59 mg (0.704 mmol, 1.0 equiv) methoxylamine hydrochloride as starting materials to give 39 mg of a clear oil, which was crystallized from ether/hexanes to give 34 mg (14%) of white crystals: mp 135-136° C.; Anal. calcd for C18H24N4O3: C, 62.77; H, 7.02; N, 16.27. Found: C, 62.64; H, 6.87; N, 16.47.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-6cc62182cd1b46c980be62bb0770626c
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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