HCID 53875714, compound → HCID 86757151, compound

HRID 1385117Notes

Reaction equation

HRID 1385117 reaction equation
C([O:8][NH:9][C:10]([CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:25]=[C:24]2[C:20]([C:21]([CH2:31][CH3:32])=[N:22][N:23]2[CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:19][CH:18]=1)=[O:16])=[O:11])C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[OH:8][NH:9][C:10]([CH2:12][CH2:13][NH:14][C:15]([C:17]1[CH:25]=[C:24]2[C:20]([C:21]([CH2:31][CH3:32])=[N:22][N:23]2[CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:19][CH:18]=1)=[O:16])=[O:11]

Participants

3

Reactant 1

HCID 53875714HCID 53875714, compound

Product 1

HCID 86757151HCID 86757151, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

This compound was prepared according to the method of Example 38, using 203 mg (0.467 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carboxylic acid (2-benzyloxycarbamoyl-ethyl)-amide as starting material and 50 mg of Pd(OH)2/C (Pearlman's catalyst) as catalyst, to give 147 mg (91%) of a white powder: mp 166-169° C.; Anal. calcd for C18H24N4O3: C, 62.77;H, 7.02; N, 16.27. Found: C, 62.58; H, 7.12; N, 16.27.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2db094cb05df45b8a2580074eb7fdc6d
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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