HCID 86757152, compound → HCID 21360896, compound

HRID 1385119Notes

Reaction equation

HRID 1385119 reaction equation
C([O:8][NH:9][C:10]([CH2:12][N:13]([CH3:32])[C:14]([C:16]1[CH:24]=[C:23]2[C:19]([C:20]([CH2:30][CH3:31])=[N:21][N:22]2[CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[CH:18][CH:17]=1)=[O:15])=[O:11])C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[OH:8][NH:9][C:10]([CH2:12][N:13]([CH3:32])[C:14]([C:16]1[CH:24]=[C:23]2[C:19]([C:20]([CH2:30][CH3:31])=[N:21][N:22]2[CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[CH:18][CH:17]=1)=[O:15])=[O:11]

Participants

3

Reactant 1

HCID 86757152HCID 86757152, compound

Product 1

HCID 21360896HCID 21360896, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

This compound was prepared according to the method of Example 38, using 126 mg (0.290 mmol, 1.0 equiv) 1cyclopentyl-3ethyl-1H-indazole-6-carboxylic acid (benzyloxycarbamoyl-methyl)-methyl amide as starting material and 40 mg of Pd(OH)2/C (Pearlman's catalyst) as catalyst, to give 78 mg (78%) of a light tan powder: mp 63° C. (dec); HRMS calcd for C18H24N4O3+H: 345,19285. Found: 345.1912.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5acc0b4ff84a4702bdd7c0fe19de5f1a
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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