Adipic Acid → HCID 54052130, compound

HRID 1385757Notes

Reaction equation

HRID 1385757 reaction equation
Cl.[CH2:2]([O:9][C:10](=[O:16])[C@@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:17]([OH:26])(=O)[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:24])=O>CCOC(C)=O>[CH2:2]([O:9][C:10]([C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:22](=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18][C:17]([N:12]1[CH2:13][CH2:14][CH2:15][C@H:11]1[C:10]([O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:16])=[O:26])=[O:16])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 196Adipic AcidHCID 2733413Proline benzyl ester hydrochloride

Product 1

HCID 54052130HCID 54052130, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using General Procedure A with 1.0 g (4.1 mmol) L-Proline benzyl ester hydrochloride and 300 mg (2.1 mmol) adipic acid afforded, after flash chromatography (EtOAc), 1.07 g (100%) of the title compound as a colorless oil. MS m/e (%): 521 (M+H+, 100).

Workup

  1. customafforded

Sources & evidence

ORD record
ord-59f44fa4ced44e50b0135b1f99f62f85
Source dataset
uspto-grants-2001_07
Patent number
US06262089B1

Reaction notes

Loading…