7-Aminoheptanoic acid → HCID 86755329, compound

HRID 1385806Notes

Reaction equation

HRID 1385806 reaction equation
N[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[C:11]([CH2:14][NH:15][C:16]1[C:17]([I:32])=[C:18]([C:29](Cl)=[O:30])[C:19]([I:28])=[C:20]([NH:23][CH2:24][C:25](=[O:27])[CH3:26])[C:21]=1[I:22])(=[O:13])[CH3:12].CC([N:36](C)C)=O>>[C:11]([CH2:14][NH:15][C:16]1[C:17]([I:32])=[C:18]([C:29]([NH:36][CH:5]([CH2:4][CH2:3][CH3:2])[CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[O:30])[C:19]([I:28])=[C:20]([NH:23][CH2:24][C:25](=[O:27])[CH3:26])[C:21]=1[I:22])(=[O:13])[CH3:12]

Participants

4

Reactant 3

HCID 135807-Aminoheptanoic acidHCID 31374DimethylacetamideHCID 21715954HCID 21715954, compound

Product 1

HCID 86755329HCID 86755329, compound

Conditions

Temperature
80 °C

Procedure

To a solution of 7-aminoheptanoic acid (0.8 g, 5.5 mmol) in DMA (20 mL) was added MDTA-Cl (X) (2.8 g, 4.2 mmol) and the mixture stirred at 80° C. for 24 h. DMA was removed. To the residue water was added. The solid material was collected and recrystallized from EtOH to furnish the pure title compound XIIIc (1.02 g, 31%).

Workup

  1. customDMA was removed
  2. additionTo the residue water was added
  3. customThe solid material was collected
  4. customrecrystallized from EtOH

Sources & evidence

ORD record
ord-4ce8c8090fe34d86be0b4b77f7cc34e6
Source dataset
uspto-grants-2001_07
Patent number
US06264916B1

Reaction notes

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