反应详情

A mixture of 3-(2,6-dimethylbenzyloxy)-5-methyl-2-nitropyridine (1.9 g, 6.99 mmol), iron powder (6.4 g), concentrated HCl (0.15 ml), water (1.5 ml) and 95% ethanol (35 ml) was refluxed for 1.0 h. The reaction mixture was filtered over celite and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel, using methylene chloride:methanol (100:4) as eluent to give 1.56 g (92%) of the title compound.

1. temperaturewas refluxed for 1.0 h
2. filtrationThe reaction mixture was filtered over celite
3. customthe solvent was removed under reduced pressure
4. customThe residue was purified by column chromatography on silica gel