Aminoacetaldehyde dimethyl acetal → HCID 21182208, compound

HRID 1386525Notes

Reaction equation

HRID 1386525 reaction equation
[CH3:1][C:2]1([CH3:10])[C:6](=[O:7])[O:5][C:4]([CH:8]=[CH2:9])=[N:3]1.[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH2:15]>COC(C)(C)C>[CH3:11][O:12][CH:13]([O:16][CH3:17])[CH2:14][NH:15][C:6]([C:2]([NH:3][C:4](=[O:5])[CH:8]=[CH2:9])([CH3:10])[CH3:1])=[O:7]

Participants

4

Reactant 2

HCID 89728Aminoacetaldehyde dimethyl acetalHCID 98127942-Ethenyl-4,4-dimethyl-1,3-oxazol-5(4H)-one

Product 1

HCID 21182208HCID 21182208, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

62.62 g (0.45 mol) of 4,4-dimethyl-2-vinyl-4H-oxazol-5-one (azalactone) are introduced into 275 g of tert-butyl methyl ether. 47.34 g (0.45 mol) of aminoacetaldehyde dimethyl acetal are slowly added with stirring. The product is formed as a white precipitate, which is filtered off, washed with tert-butyl methyl ether and dried, giving 106 g (96.5% of theory) of a white product of melting point 80-82° C.

Workup

  1. customThe product is formed as a white precipitate, which
  2. filtrationis filtered off
  3. washwashed with tert-butyl methyl ether
  4. customdried
  5. customgiving 106 g (96.5% of theory) of a white product of melting point 80-82° C.

Sources & evidence

ORD record
ord-5b0a318e3fbf4760bc834dee945cea1b
Source dataset
uspto-grants-2001_07
Patent number
US06265509B1

Reaction notes

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