反应详情

温度

60 °C

A mixture of 2,4-Dihydroxybenzaldehyde (5.52 g), potassium carbonate (6.08 g) and octyl bromide (7.73 g) in acetonitrile (55 ml) was stirred for 16 hours at 60° C. The solvent of reaction mixture was removed under reduced pressure, and the residue was dissolved in ethyl acetate, and washed with water and brine. The separated organic layer was dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel and eluted with (hexane:ethyl acetate=9:1) to give 2-Hydroxy-4-octyloxybenzaldehyde (6.73 g).

1. customThe solvent of reaction mixture
2. customwas removed under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with water and brine
5. dry with materialThe separated organic layer was dried over magnesium sulfate
6. filtrationThe magnesium sulfate was filtered off
7. customthe filtrate was evaporated under reduced pressure
8. washeluted with (hexane:ethyl acetate=9:1)