Hydrogen Bromide → HCID 21182300, compound

HRID 1386601Notes

Reaction equation

HRID 1386601 reaction equation
Cl.[CH2:2]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH2:15][CH2:16][N:17]2[CH2:21][CH2:20]OC2=O)=[CH:10][CH:9]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C(OC(C)C)(C)C.[BrH:30]>C(O)(=O)C>[BrH:30].[BrH:30].[CH2:2]([C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:15][CH2:16][NH:17][CH2:21][CH2:20]2)=[CH:12][CH:13]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 7914Diisopropyl EtherHCID 21182460HCID 21182460, compound

Product 1

HCID 21182300HCID 21182300, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 3-[2-(4-Hexylphenylamino)ethyl]-2-oxo-oxazolidine hydrochloride (2.131 g) in 25% hydrobromic acid in acetic acid (13.04 ml) was stirred for 96 hours at ambient temperature. The reaction mixture was pulverized with diisopropyl ether. The precipitate was collected by filtration and added to ethanol (15 ml). The solution was refluxed for 5 hours and pulverized with diisopropyl ether. The precipitate was collected by filtration to give 1-(4-n-Hexylphenyl)piperazine dihydrobromide (2.413 g).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. additionadded to ethanol (15 ml)
  3. temperatureThe solution was refluxed for 5 hours
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-47b3edd6a7e7468cae171d9bdeb7df37
Source dataset
uspto-grants-2001_07
Patent number
US06265536B1

Reaction notes

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