反应详情

温度

60 °C

As 510 mg (7.5 mmol) of sodium ethoxide was stirred in 5 mL toluene, 1.16 g (10.0 mmol) of t-butyl acetate was added dropwise at room temperature to the solution. Then, 956 mg (5.0 mmol) of 5-ethoxycarbonylfuro[2,3-c]pyridine dissolved in 5 mL of toluene was added dropwise at room temperature to the above solution. After all the solution had been added, the reaction mixture was heated to 60° C., and a reaction was carried out for 3 hours. The reaction solution was then cooled to 5° C. and was neutralized with 450 mg (7.5 mmol) of acetic acid as the temperature was held 5-10° C., the solution was stirred for 30 minutes as the temperature was maintained, 1 mL water was then added, and the solution was returned to room temperature. The organic layer was separated, the aqueous layer was extracted twice with 5 mL of methylene chloride, and the combined organic layer was dried with anhydrous magnesium sulfate and then concentrated in a rotary evaporator. The resulting solids were recrystallized from a mixed solvent of toluene-hexane mixture, giving 933 mg (80% yield) of ethyl β-oxo-5-furo[2,3-c]pyridinepropionate in a purity of 99% by HPLC.

1. additionwas added dropwise at room temperature to the above solution
2. additionAfter all the solution had been added
3. temperatureThe reaction solution was then cooled to 5° C.
4. customwas held 5-10° C.
5. temperaturewas maintained
6. customwas returned to room temperature
7. customThe organic layer was separated
8. extractionthe aqueous layer was extracted twice with 5 mL of methylene chloride
9. dry with materialthe combined organic layer was dried with anhydrous magnesium sulfate
10. concentrationconcentrated in a rotary evaporator
11. customThe resulting solids were recrystallized from a mixed solvent of toluene-hexane mixture