HCID 178452156, compound → HCID 178515850, compound

HRID 1386672Notes

Reaction equation

HRID 1386672 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:28])([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:19][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[OH:28][C:11]1([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[NH:27][N:26]=[N:25][N:24]=3)=[CH:19][CH:18]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 178452156HCID 178452156, compound

Product 1

HCID 178515850HCID 178515850, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of 105 mg (0.27 mmol) of 1-t-butoxycarbonyl-4-hydroxy-4-(3-(4-(1H-tetrazol-5-yl)phenyl)-propyl)piperidine (from EXAMPLE 2, Step E) in 5 mL of 0.5 N HCl in MeOH was stirred at rt for 20 h. The solution was concentrated and dried under vacuum to afford the title compound: HPLC B: 3.10 min.

Workup

  1. concentrationThe solution was concentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-df621917ffdb477cb2ceef702e743c6f
Source dataset
uspto-grants-2001_07
Patent number
US06265434B1

Reaction notes

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