Trifluoroacetic acid → HCID 69829296, compound

HRID 1386946Notes

Reaction equation

HRID 1386946 reaction equation
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])=[C:6]([F:19])[CH:5]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]([OH:14])=[O:13])=[C:6]([F:19])[CH:5]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69829960HCID 69829960, compound

Product 1

HCID 69829296HCID 69829296, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-tert-butoxycarbonylmethoxy-3-fluoro-benzoic acid methyl ester in CH2Cl2 was treated with trifluoroacetic acid (14.9 ml, 130 mmol, 10.6 eq.) (20 ml) for 3.5 hrs. at r.t. Following evaporation to dryness, the title compound (2.77 g, 99% yield) was obtained as an off-white solid. MS: m/e=228 (M+).

Workup

  1. customat r.t
  2. customevaporation to dryness

Sources & evidence

ORD record
ord-316cf81f27b4497bbc1b0d68bf1cda83
Source dataset
uspto-grants-2001_07
Patent number
US06265426B1

Reaction notes

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