HCID 10667130, compound → HCID 21182964, compound

HRID 1386970Notes

Reaction equation

HRID 1386970 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[C:12]3[CH:27]=[CH:26][CH:25]=[CH:24][C:13]=3[S:14][C:15]=2[C:16]2[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=2)=[O:10])=[CH:5][CH:4]=1>CCOC(C)=O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]([C:11]2[C:12]3[CH:27]=[CH:26][CH:25]=[CH:24][C:13]=3[S:14][C:15]=2[C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)=[O:10])=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 10667130HCID 10667130, compound

Product 1

HCID 21182964HCID 21182964, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By essentially following the procedure outlined in Example 1, Part D, the title compound was prepared from 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-methoxyphenyl ketone (Part B) as a yellow solid in 93% yield following radial chromatography (SiO2; gradient of 20-40% EtOAc in hexanes).

Sources & evidence

ORD record
ord-4a06a6a8f502431cab6ef48a90c09a76
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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