HCID 10785526, compound → HCID 11791731, compound

HRID 1386989Notes

Reaction equation

HRID 1386989 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[C:18]([C:20]2[CH:25]=[CH:24][C:23]([O:26]C)=[CH:22][CH:21]=2)=[CH2:19])=[CH:5][CH:4]=1>CCOC(C)=O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[C:18]([C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)=[CH2:19])=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 10785526HCID 10785526, compound

Product 1

HCID 11791731HCID 11791731, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By essentially following the procedure detailed in Example 5, Part B, the title compound was prepared from methyl 4-[1-[2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]ethenyl]phenyl ether (Part A) in 67% yield as a yellow solid following radial chromatography (SiO2; gradient of 20-40% EtOAc in hexanes).

Sources & evidence

ORD record
ord-aa8d3c85fc3a4145ac63f249d4edce22
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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